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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PDE1A All Species: 13.03
Human Site: S480 Identified Species: 31.85
UniProt: P54750 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54750 NP_001003683.1 535 61252 S480 R R S N T K G S M S D G S Y S
Chimpanzee Pan troglodytes XP_515959 553 63273 S480 R R S N T K G S M S D G S Y S
Rhesus Macaque Macaca mulatta XP_001101568 545 62242 G480 L R R P N A K G S M S D G S Y
Dog Lupus familis XP_532505 595 67382 G523 Q A E E G A A G K T E K K T S
Cat Felis silvestris
Mouse Mus musculus Q61481 565 64452 S500 R R S N T K G S V C D G S Y A
Rat Rattus norvegicus Q63421 768 86653 G550 V K S S G S E G S A P I N N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515772 621 69800 S480 T D T Q K K P S G K L T S N E
Chicken Gallus gallus XP_421969 641 72641 T465 R R H N F R S T A S D G A A H
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_692892 625 71088 D483 H S D R G S N D E C G G S T D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O18696 664 74836 T594 P D L R N S S T S P S S I R R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 95.2 60.5 N.A. 87.6 48.1 N.A. 72.3 65.9 N.A. 60.9 N.A. N.A. N.A. 39.3 N.A.
Protein Similarity: 100 96.3 95.9 73.6 N.A. 91.6 59.5 N.A. 79.7 73.3 N.A. 72.1 N.A. N.A. N.A. 55.7 N.A.
P-Site Identity: 100 100 6.6 6.6 N.A. 80 13.3 N.A. 20 40 N.A. 13.3 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 6.6 26.6 N.A. 93.3 40 N.A. 26.6 60 N.A. 13.3 N.A. N.A. N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 20 10 0 10 10 0 0 10 10 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 20 0 0 0 0 0 % C
% Asp: 0 20 10 0 0 0 0 10 0 0 40 10 0 0 10 % D
% Glu: 0 0 10 10 0 0 10 0 10 0 10 0 0 0 10 % E
% Phe: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 30 0 30 30 10 0 10 50 10 0 0 % G
% His: 10 0 10 0 0 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 10 10 0 0 % I
% Lys: 0 10 0 0 10 40 10 0 10 10 0 10 10 0 0 % K
% Leu: 10 0 10 0 0 0 0 0 0 0 10 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 20 10 0 0 0 0 0 % M
% Asn: 0 0 0 40 20 0 10 0 0 0 0 0 10 20 0 % N
% Pro: 10 0 0 10 0 0 10 0 0 10 10 0 0 0 0 % P
% Gln: 10 0 0 10 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 40 50 10 20 0 10 0 0 0 0 0 0 0 10 10 % R
% Ser: 0 10 40 10 0 30 20 40 30 30 20 10 50 10 40 % S
% Thr: 10 0 10 0 30 0 0 20 0 10 0 10 0 20 0 % T
% Val: 10 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 30 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _